Cardiovascular Issues
Heart Disease, Poor Blood Flow, Other Issues
Neurological Issues
Stroke, TBI, MS,
SCI, Parkinsons
Mental Health
Depression, PTSD, Anxiety, ADD, MS, Addictions
Regenerative Medicine
Personal Messenger Signaling Cell Therapy
Neuropathy Treatment
Neuropathy Pain Therapy, Pain, Numbness
Jeffersonville, Indiana (812) 913-4416
Jeffersonville, Indiana
(812) 913-4416
Stroke, TBI, Nerve Damage, Regenerative and Cell Therapy Treatments
We specialize in safe, effective, and integrative treatments for chronic and neurological conditions - Perispinal etanercept treatment for stroke and TBI
At Kentuckiana Integrative Medicine, we offer a unique, physician-led treatments for stroke and TBI using perispinal etanercept treatment that targets the brain. This expert technique is exclusively performed by Dr. Rafael F. Cruz, MD, who brings over 30 years of experience in emergency medicine, anesthesiology, and integrative care. The complete treatment takes about a week, but many patients report noticeable improvements in as little as two hours after the first session. Because of its effectiveness and rarity, we see patients traveling from all 50 states, Europe, and beyond to receive this advanced therapy.
Disclaimer Notice regarding personal messenger signaling cell therapy and regenerative medicine pain relief injections.
DISCLAIMER NOTICE: We make NO claims that ANY of our supportive therapies can cure or heal any disease process. Our treatments and therapies can provide symptom relief and support your bodies self-healing mechanisms. Only FDA approved therapies can be declared curative of disease. All information including video testimonials are purely educational and no implied or direct claims of a patient experiencing a benefit are made. Results CANNOT be guaranteed and vary based on multiple variables especially patient’s level of health and receptiveness. Only GOD, you and FDA therapies can cure you of a disease. Additionally, educational information regarding many of the services and or commercial products discussed are NOT offered. Our focus is on Injections of Prolozone, Prolotherapy, Platelet Rich Plasma, Harvested Adipose “Fat” and Bone Marrow Messenger Signaling Cells all collected administered as within same day procedure FDA guidelines with minimal manipulation [no enzymes are used.]
Regarding Stem Cell Injection Therapy and Regenerative Medicine Pain Relief Injections, we are one of the most experienced clinics in the USA. Our most experienced physician has been providing these services since 2010 which were the early days of Platelet Rich Plasma and Stem Cell Therapy. We are extremely experienced in the use of ultrasound and fluoroscopy guided injections offering precision needle placement when needed. We focus on FDA approved procedures and products [especially wound care that are even approved by some insurances] and FDA approved and permitted “same day procedures” that include but are not limited to Collecting [Harvesting] a patient’s Adipose “Belly Fat” Messenger Signaling Cells and Bone Marrow Messenger Signaling Cells, Platelet Rich Plasma Injections [from your blood], Prolozone and Prolotherapy. Collection of “fat” messenger signaling cells and bone marrow messenger signaling cells can be done very comfortably and with very little or no pain with proper numbing techniques. Currently, the FDA allows the above “same day procedures” or injection therapies under FDA rule 21 CFR 1271.15. The FDA has approved a very few injectable commercial regenerative products under FDA rule 21 CFR 1271.10 mostly wound care products for homologous use with skin problems such as burns and wounds.
Musculoskeletal Issues & Pain Conditions
Unique Conditions We Treat
Dr. Rafael F. Cruz, MD
Dr. Rafael F. Cruz, MD is a nationally recognized expert in Integrative Medicine, combining conventional medical practices with holistic, natural therapies. As the founder of Kentuckiana Integrative Medicine, he offers advanced, patient-centered treatments that target the root causes of complex health issues. With over 30 years of clinical experience, Dr. Cruz collaborates closely with patients and their primary doctors to deliver personalized care that promotes long-term healing.
His credentials include board certification in Emergency Medicine (1997–2017), advanced training in ultrasound- and fluoroscopic-guided injections, regenerative therapies (including PRP, prolotherapy, and signaling cell treatments), and certifications in IV Chelation, Plaquex, and nutritional therapy.
What Our Patients Say About Us
We are a leader in Regenerative Medicine, Adipose “Fatty Tissue” and Bone Marrow Personal Messenger Signaling Cell Therapy Injection Therapy, PRP – Platelet Rich Plasma, Prolotherapy & Prolozone Injection Therapies. We are one of the most experienced, advanced and progressive medical centers using regenerative medicine, functional medicine, and integrative medicine to assist patients with complex medical problems for which traditional medicine has few answers. We have more experience in regenerative and integrative medicine than most any other practice in the area with over 30 years of experience delivering personalized care by a team of highly skilled and knowledgeable physicians whose focus is to bring the most innovative and leading-edge therapies to this region of the country. We combine the best of conventional and integrative medicine in an effort to provide our patients with the best outcomes.
Our physicians are trained in various integrative medicine disciplines to treat musculoskeletal issues, orthopedic injuries and various other health conditions. With more than 100 combined years of clinical experience, we pride ourselves on our knowledge of integrative and complimentary medicine to relieve your symptoms and get to the source of your pain.
At Kentuckiana Integrative Medicine, we treat the whole person—not just your symptoms. Our approach focuses on identifying and addressing the root causes of illness to promote long-term healing and vitality. By blending the best of conventional and alternative medicine, our experienced team helps patients restore energy, strength, and overall well-being. We understand that the body has remarkable self-healing capabilities, which can be diminished by age, stress, lifestyle, or environmental factors. That’s why we use advanced integrative and functional therapies to give your body the tools it needs to recover and thrive.
Located just five minutes from Louisville, KY, Kentuckiana Integrative Medicine is a regional leader in innovative, non-surgical treatments. Our clinic offers regenerative solutions such as platelet-rich plasma (PRP), personal messenger signaling cell therapy, prolozone, and hormone optimization. Whether you’re dealing with chronic pain, fatigue, hormone imbalance, or complex medical issues, our doctors draw on more than 100 years of combined clinical experience to create personalized treatment plans that deliver real results. We go beyond symptom management to support your body’s natural ability to heal and rebuild. From your initial consultation through every step of your care, our focus is helping you feel better, function better, and live with renewed energy. If traditional medicine hasn’t provided the answers you need, Kentuckiana Integrative Medicine offers an experienced, compassionate, and results-driven alternative. Discover how our whole-person approach can help you reclaim your health and get back to living fully. Your body has incredible potential—more than you might realize. If you’re feeling low on energy or not functioning like you used to, there’s good news: we can help you reclaim that vitality. Our approach supports your body’s natural healing processes while also working to restore hormonal balance, especially as it changes with age. These treatments are designed to help you move better, feel stronger, and tap back into the energy and resilience you once had. At Kentuckiana Integrative Medicine, we use proven, safe functional medicine strategies focused on chronic disease prevention and management. Whether you’re a man or woman, young or aging, we tailor therapies to support healing, repair, and restoration—helping you regain lost function and boost your overall health.
During your visit, we’ll take time to understand your full health story. That includes your medical history, lifestyle, and a comprehensive physical exam. This lets us create a plan to improve your current health, maintain your wellness, and prevent future issues by harnessing your body’s natural abilities. Our mission is simple: to restore your energy, health, and strength through integrative medical care that manages and prevents chronic conditions.
