At Kentuckiana Integrative Medicine, we offer a unique, physician-led treatment that targets the brain through a specialized pathway in the neck, making the process safer and more precise. This expert technique is exclusively performed by Dr. Rafael F. Cruz, MD, who brings over 30 years of experience in emergency medicine, anesthesiology, and integrative care. The complete treatment takes about a week, but many patients report noticeable improvements in as little as two hours after the first session. Because of its effectiveness and rarity, we see patients traveling from all 50 states, Europe, and beyond to receive this advanced therapy.
DISCLAIMER NOTICE: We make NO claims that ANY of our supportive therapies can cure or heal any disease process. Our treatments and therapies can provide symptom relief and support your bodies self-healing mechanisms. Only FDA approved therapies can be declared curative of disease. All information including video testimonials are purely educational and no implied or direct claims of a patient experiencing a benefit are made. Results CANNOT be guaranteed and vary based on multiple variables especially patient’s level of health and receptiveness. Only GOD, you and FDA therapies can cure you of a disease. Additionally, educational information regarding many of the services and or commercial products discussed are NOT offered. Our focus is on Injections of Prolozone, Prolotherapy, Platelet Rich Plasma, Harvested Adipose “Fat” and Bone Marrow Messenger Signaling Cells all collected administered as within same day procedure FDA guidelines with minimal manipulation [no enzymes are used.]
Regarding Stem Cell Injection Therapy and Regenerative Medicine Pain Relief Injections, we are one of the most experienced clinics in the USA. Our most experienced physician has been providing these services since 2010 which were the early days of Platelet Rich Plasma and Stem Cell Therapy. We are extremely experienced in the use of ultrasound and fluoroscopy guided injections offering precision needle placement when needed. We focus on FDA approved procedures and products [especially wound care that are even approved by some insurances] and FDA approved and permitted “same day procedures” that include but are not limited to Collecting [Harvesting] a patient’s Adipose “Belly Fat” Messenger Signaling Cells and Bone Marrow Messenger Signaling Cells, Platelet Rich Plasma Injections [from your blood], Prolozone and Prolotherapy. Collection of “fat” messenger signaling cells and bone marrow messenger signaling cells can be done very comfortably and with very little or no pain with proper numbing techniques. Currently, the FDA allows the above “same day procedures” or injection therapies under FDA rule 21 CFR 1271.15. The FDA has approved a very few injectable commercial regenerative products under FDA rule 21 CFR 1271.10 mostly wound care products for homologous use with skin problems such as burns and wounds.
Heart Disease, Poor Blood Flow, Other Issues
Stroke, TBI, MS,
SCI, Parkinsons
Depression, PTSD, Anxiety, ADD, MS, Addictions
Personal Messenger Signaling Cell Therapy
Neuropathy Pain Therapy, Pain, Numbness
Dr. Rafael F. Cruz, MD
Dr. Rafael F. Cruz, MD is a nationally recognized expert in Integrative Medicine, combining conventional medical practices with holistic, natural therapies. As the founder of Kentuckiana Integrative Medicine, he offers advanced, patient-centered treatments that target the root causes of complex health issues. With over 30 years of clinical experience, Dr. Cruz collaborates closely with patients and their primary doctors to deliver personalized care that promotes long-term healing.
His credentials include board certification in Emergency Medicine (1997–2017), advanced training in ultrasound- and fluoroscopic-guided injections, regenerative therapies (including PRP, prolotherapy, and signaling cell treatments), and certifications in IV Chelation, Plaquex, and nutritional therapy.
At Kentuckiana Integrative Medicine, we treat the whole person—not just your symptoms. Our approach focuses on identifying and addressing the root causes of illness to promote long-term healing and vitality. By blending the best of conventional and alternative medicine, our experienced team helps patients restore energy, strength, and overall well-being. We understand that the body has remarkable self-healing capabilities, which can be diminished by age, stress, lifestyle, or environmental factors. That’s why we use advanced integrative and functional therapies to give your body the tools it needs to recover and thrive.
Located just five minutes from Louisville, KY, Kentuckiana Integrative Medicine is a regional leader in innovative, non-surgical treatments. Our clinic offers regenerative solutions such as platelet-rich plasma (PRP), personal messenger signaling cell therapy, prolozone, and hormone optimization. Whether you’re dealing with chronic pain, fatigue, hormone imbalance, or complex medical issues, our doctors draw on more than 100 years of combined clinical experience to create personalized treatment plans that deliver real results.
We go beyond symptom management to support your body’s natural ability to heal and rebuild. From your initial consultation through every step of your care, our focus is helping you feel better, function better, and live with renewed energy. If traditional medicine hasn’t provided the answers you need, Kentuckiana Integrative Medicine offers an experienced, compassionate, and results-driven alternative. Discover how our whole-person approach can help you reclaim your health and get back to living fully.
Cindy Palazzo2025-04-18Trustindex verifies that the original source of the review is Google. Truly an answer to prayer! I had back pain that had gotten progressively worse for several years. I had two back surgeries last year and still could not stand for more than 5 or 10 minutes without pain. I had 3 different vertebrae that were bone on bone causing a lot of pain. I received 3 sets of lumbar stem cell injections, along with PRP and ozone from Dr. Cruz, and I feel like a new person!! I walked 2 miles with no pain at all, and that was days after the last injections. I started to feel results after the first set of injections. Not only that, I have so much energy and no more brain fog!!! Also, I have Rheumatoid Arthritis and had developed rheumatoid nodules on the balls of my feet causing pain when I walked. Dr. Cruz injected the main one that was causing pain at the time with PRP and ozone to see if that would help. Within 2 hours the nodule was smaller and completely pain free!!!! I am so impressed with Dr. Cruz and his staff!!! Kitty is so funny and sweet and Great with needles!!! I hardly felt the needle go in for the blood draw or the IV. Everyone there makes you feel so comfortable and important!! Beau Hoffman2025-04-15Trustindex verifies that the original source of the review is Google. My name is Tanya Hoffman, age 55 and a weightlifter. I have had pain in my right hip for at least four years maybe longer to where I’m at a constant pain around 6-8 on a daily. It’s gotten so bad lately that it wakes me up almost in tears at 2am. Came in to see Dr Cruz and within 15 minutes my pain went from standing at a 7 pain threshold to being gone. Eric L2025-03-12Trustindex verifies that the original source of the review is Google. I'm very impressed with Dr. Cruz and his staff! This place is a sort of a last hope when all else has failed, and I'm thankful it's here :) I know Dr. Cruz cares deeply about his patients: One day during an appointment, Dr. Cruz prescribed a medicine from a compounding pharmacy -- that evening, he called me because the pharmacy needed my SSN, address, etc. Unfortunately, the pharmacy somehow lost the data three times over the course of the evening. Dr. Cruz called me to keep me informed, and ultimately stayed until well after 8:00 pm to get the prescription ordered. I've never had a doctor give up his evening for me! All he had to do was to go home and try again the next day, but he stuck it ou on my behalf, and I'm very grateful for his effort. The staff are also great: Kitty, Karen and Miriam (a Physical Therapist) all have helped me so much over the course of my visits. They are professional, competent and kind. I think, instead of making this my last stop, in the future I should make this my first stop instead! Hopeful American2024-12-26Trustindex verifies that the original source of the review is Google. Dr. Cruz saved my Peace of Mind! He was the only doctor who had the knowledge that I needed to protect myself & spouse, should we have become infected. He gave me EVERYTHING I NEEDED TO REMAIN SANE IN AN INSANE WORLD! God bless you, Dr. Cruz and staff! Ted Chittum2024-12-09Trustindex verifies that the original source of the review is Google. This past spring I injured myself playing with my granddaughter, resulting in a 50% tear of my left Achilles tendon. My options seem to be surgery or 6-8 months in a boot. After a couple of weeks investigating other treatments I discovered Kentuckiana Medicine in Jeffersonville, In. After a consultation with Dr. Rafael Cruz, I decided to go with a 3rd option: Regenerative medicine injections. The treatment consisted of 3 injection sessions over a period of a month which provided nearly immediate relief and complete healing so much so that I was completely pain free and golfing a month after the sessions were completed. I highly recommend investigating this option as an alternative for surgery or months of rest. Thank you Dr. Cruz Krown SayDat2024-12-05Trustindex verifies that the original source of the review is Google. My name is Ken Mcmickens 37 yrs old Im from richmond, Va, but i live in louisville, Ky. For almost 3 months I've been in major pain in my shoulder and feet and just a 1 hour session with Dr Cruz has me feeling better than I've felt in almost 3months with the ozone 3 injections I recommend going to see him if you really want results. Plus he has good conversation topics lol.. Thanks Dr Cruz Judy Land2024-12-02Trustindex verifies that the original source of the review is Google. In 2021, desperate to find a doctor who'd give me ivermectin and finding none, I was referred by a friend to America's Frontline Doctors, and through that organization, referred to Kentuckiana Integrative Medicine. What a relief in a stressful, paranoid world! I had a zoom-call visit with Dr. Rafael Cruz, and got perscriptions through the mail that I've used since (after contracting Covid and other upper respiratory illnesses). Thanks so much for making this service available! Super satisfied customer! zeropoint music ASCAP2024-11-19Trustindex verifies that the original source of the review is Google. Haven't gotten the consultation yet need to know the self pay quotation on the stroke procedure Christopher Neal2024-09-16Trustindex verifies that the original source of the review is Google. Dr Cruz is very good. He takes the time to explain the treatment and the way ahead. Thank you Dr Cruz the therapy was extremely helpfulVerified by TrustindexTrustindex verified badge is the Universal Symbol of Trust. Only the greatest companies can get the verified badge who has a review score above 4.5, based on customer reviews over the past 12 months. Read more